CIVM
Home facilities research publications collaboration training staff gallery shareddata sharedcode about contact
only search CIVM


 

CIVM research

Ergys Subashi, PhD candidate, Medical Physics

Contrast-enhanced MRI in small animal tumor models

back to research page

Dynamic contrast-enhanced (DCE) MRI is widely used as a quantitative imaging method to monitor tumor response to therapy. The simultaneous challenges of increasing temporal and spatial resolution in a setting where the signal from the much smaller voxel is weaker have made this MR technique difficult to implement in small-animal imaging.

This movie shows:

  • Contrast agent kinetics in 6 consecutive slices in a colon adenocarcinoma (HT-29) implanted in the mammary fat pad of a mouse.
  • This acquisition (field of view = 20x20x20 mm3, matrix = 128x128x128, and temporal resolution = 10 seconds) has an improvement of more than an order of magnitude in spatiotemporal resolution over previous methods published.
  • Arrows point to the distinct enhancement patterns in regions.
  • Given that the voxel size in this study is 160 µm, it is remarkable that the enhancement pattern is so heterogeneous even in such close locations.
movie

REFERENCES

This manuscript with more detail is now in press:

Ergys Subashi, Everett J. Moding, Gary P. Cofer, James R. MacFall, David G. Kirsch, Yi Qi, G. Allan Johnson, A comparison of keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models, Medical Physics in press 2013.

 

---